A Little Capital in the Right Places Can Move Whole Systems Forward
In complex industries, a small number of bottlenecks decide where value accumulates and where progress stalls.
We find those constraints and invest in startups positioned to resolve them.
01 /
THE PROBLEM
The bottlenecks that matter most are often hard to find
There's no shortage of capital. There's no shortage of important problems. The hard part is knowing where a little capital solves the biggest problems.
The constraints that matter most can sit upstream of symptoms, hide inside processes nobody is paying much attention to, and shift before anyone notices.
02 /
THE RESEARCH
Understanding a market means going much deeper than the market itself
We deconstruct systems into the technologies, capabilities, infrastructure, institutions and other dependencies they rely on, then analyze how those pieces interact and change over time.
That's where hidden bottlenecks often become visible.
03 /
HOW WE WORK
Deconstruct the system. Find the bottlenecks. Deploy capital to clear them.
01
Since 2006
The research began at Intel and Harvard, and has evolved ever since.
02
Today
The discoveries continue, with each new market adding to what we've learned about how companies, markets and social systems behave.
03
How we use it
We use what we’ve learned to find opportunities others may overlook, from investments in individual companies to bottlenecks affecting entire industries. Our work brings us into collaboration with leading companies, research institutions and specialists across a remarkable range of scientific and technical disciplines.
04 / SECTORS
Where we've deployed capital.
AGRITECH
Investments across crop science, biological inputs, and the systems that connect them to growers.
DIAGNOSTICS
Investments in the infrastructure of clinical testing, at-home care, and the data layer underneath both.
MULTI-INDUSTRY
Direct investments where bottlenecks cross sector lines. Electric vehicles, energy efficiency, virtual healthcare, neurology, and other emerging fields.
05 / RECENT ACTIVITY
Portfolio
MAY 2026
Getlabs acquired by Function Health to expand at-home care
APR 2026
Resurrect Bio raises $8M Series A
MAR 2026
Viome sells over 500,000 AI-powered health testing kits
MAR 2026
Pyrra Technologies acquired by AlertMedia
FEB 2026
Puna Bio raises round for non-GMO seed treatment
JAN 2026
IBI Ag secures $6.1M
JAN 2026
Hone Health closes $33M Series A and acquires ivee
DEC 2025
Solasta Bio closes $14M